THE CORRELATION BETWEEN LDL/HDL RATIO AND ACUTE CORONARY SYNDROME AMONG PATIENTS AT RSUD ABDUL WAHAB SJAHRANIE SAMARINDA

  • Monika Widi Sherina Universitas Mulawarman
  • Siti Laboratorium Ilmu Biokimia, Fakultas Kedokteran, Universitas Mulawarman
  • Muhammad Laboratorium Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Mulawarman
Keywords: Acute coronary syndrome;, LDL ratio;, HDL ratio;

Abstract

Acute coronary syndrome is part of clinical manifestation of coronary heart disease. It is a collection of clinical symptoms caused by the presence of atherosclerotic plaques. LDL is oxidized lipoprotein produced in the body which is captured by macrophage. It may be accumulated in blood vessels and can cause atherosclerotic plaques. HDL transports cholesterol from blood vessels and carries it back to the liver to directly flush it in order to prevent atherosclerotic process. High LDL level and low HDL level accompanied by their ratio increase are associated with an increased risk of heart disease. This study aims to find the correlation between LDL/HDL ratio and acute coronary syndrome among patients admitted to ICCU at RSUD Abdul Wahab Sjahranie Samarinda. The design of this study was analytical observational with cross-sectional method. Using purposive sampling technique, the medical records of patients admitted to ICCU at RSUD Abdul Wahab Sjahranie Samarinda in 2019 were used as the data. The data were analyzed using Chi-square test. Out of 56 samples, 27 patients (48.2%) had low LDL/HDL ratio and 29 patients (51.8%) had high LDL/HDL ratio. Based on the Chi-square test, it was found that p value was 0,035 (p < 0,05). It can be concluded that there is  correlation between LDL/HDL ratio and acute coronary syndrome.

 

Keywords: Acute coronary syndrome, LDL/HDL ratio

References

Bertalina. (2015). Hubungan Asam Lemak Jenuh, Tak Jenuh Ganda dan Serat Dengan Rasio LDL/HDL Pada Penderita Jantung Koroner Di Poli Jantung RSUD Dr. HI. Abdu Moeloek. Jurnal Dunia Kesmas 4, 196–202.
Chen, Q. J., Lai, H. M., Chen, B. D., Li, X. M., Zhai, H., He, ….,Yang, Y. N. (2016). Appropriate LDL-C-to-HDL-C ratio cutoffs for categorization of cardiovascular disease risk factors among uygur adults in xinjiang, China. International Journal of Environmental Research and Public Health.
Fransiskus, R., & Ginting, S. (2019). Karakteristik Penderita Infark Miokard Akut di Poliklinik kardiovaskuler RSUP H . Adam Malik Medan tahun 2019. 1–8.
Fuster, V., & Kovacic, J. C. (2014). Acute coronary syndromes: Pathology, diagnosis, genetics, prevention, and treatment. Circulation Research.
Guyton & Hall (2017). Guyton dan Hall Buku Ajar Fisiologi Kedokteran. In Elsevier, Singapore.
Jellinger, P. S., Handelsman, Y., Rosenblit, P. D., Bloomgarden, Z. T., Fonseca, V. A., Garber, A. J., …,Davidson, M. (2017). American Association Of Clinical Endocrinologists And American College Of Endocrinology Guidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
Kumar, L., & Das, A. L. (2018). Assessment of Serum Lipid Profile in Patients of Coronary Artery Disease: A Case-Control Study. International Journal of Contemporary Medical Research [IJCMR], 5(5), 59–62. https://doi.org/10.21276/ijcmr.2018.5.5.42
Kusumawati, V. (2018). Nilai Fraksi Lemak LDL, Trigliserida, Kolesterol Total dan Rasio LDL : HDL Berpengaruh terhadap Risiko Penyakit Jantung Koroner di RSUD Dr. Harjono Ponorogo tahun 2017 [STIKES BHAKTI HUSADA MULIA.]. http://repository.stikes-bhm.ac.id/id/eprint/284
Muhibbah, M., Wahid, A., Agustina, R., & Illiandri, O. (2019). Karakteristik Pasien Sindrom Koroner Akut Pada Pasien Rawat Inap Ruang Tulip Di Rsud Ulin Banjarmasin. Indonesian Journal for Health Sciences, 3(1), 6.
Parvin, D., Baul, S. K., Hossain, S. R., Munshi, S., Hadiuzzaman, M., & Fatema, K. (2019). Pattern and Prevalence of Dyslipidemia among Patients with Acute Coronary Syndrome Admitted in a Tertiary Level Hospital. Bangladesh Heart Journal.
PERKI. (2018). Pedoman Tata Laksana Sindrom Koroner Akut 2018. In Perhimpunan Dokter Spesialis Kardiovaskular Indonesia (p. 76).
Reith, C., & Armitage, J. (2016). Management of residual risk after statin therapy. Atherosclerosis.
Riskesdas. (2018). Hasil Utama Riset Kesehata Dasar (RISKESDAS).
Shih, J. Y., Chen, Z. C., Chang, H. Y., Liu, Y. W., Ho, C. H., & Chang, W. T. (2019). Risks of age and sex on clinical outcomes post myocardial infarction. IJC Heart and Vasculature, 23, 100350.
Sinulingga, B. O. (2019). Pengaruh konsumsi serat dalam menurunkan kadar kolesterol. Jurnal Penelitian Sains, 21(3), 163–167.
Siregar, F. A., & Makmur, T. (2020). Metabolisme lipid dalam tubuh. Jurnal Inovasi Kesehatan Masyarakt, 1(2), 60–66.
Sitepu, A. M., Djafar, D. U., & Panda, A. L. (2016). Gambaran jumlah leukosit pada pasien infark miokard akut di RSUP Prof. Dr. R. D.Kandou Manado periode Januari-Desember 2015. E-CliniC, 4(2).
Susilo, C. (2015). Identifikasi Faktor Usia, Jenis Kelamin dengan Luas Infark Miokard pada Penyakit Jantung Koroner (Pjk) di Ruang ICCU RSD Dr. Soebandi Jember. The Indonesian Journal of Health Science, 6(1), 1–7.
Torry, S. R. V., Panda, L., & Ongkowijaya, J. (2014). Gambaran Faktor Risiko Penderita Sindrom Koroner Akut. E-CliniC, 2(1), 1–8.
Tumbel, M. I. S., Panda, A. L., & Pangemanan, J. (2016). Gambaran kelainan katup jantung pada pasien infark miokard di RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari 2015-31 Desember 2015. E-CliniC, 4(2).
WHO. (2017). Cardiovascular diseases (CVDs). WHO. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)
Wu, T. T., Gao, Y., Zheng, Y. Y., Ma, Y. T., & Xie, X. (2018). Atherogenic index of plasma (AIP): A novel predictive indicator for the coronary artery disease in postmenopausal women. Lipids in Health and Disease, 17(1), 1–7.
Zhong, Z., Hou, J., Zhang, Q., Zhong, W., Li, B., Li, C., Liu, Z., Yang, M., & Zhao, P. (2019). Assessment of the LDL-C/HDL-C ratio as a predictor of one year clinical outcomes in patients with acute coronary syndromes after percutaneous coronary intervention and drug-eluting stent implantation. Lipids in Health and Disease, 18(1), 1–8.
Published
2021-10-05
Section
Articles
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