KARAKTERISTIK PASIEN KETOASIDOSIS DIABETIK DI RSUD ABDUL WAHAB SJAHRANIE SAMARINDA PERIODE 2018

  • Muhammad Wiryansyah Fakultas Kedokteran Universitas Mulawarman
  • Yuliana Rahmah Retnaningrum Fakultas Kedokteran Universitas Mulawarman
  • Abdul Mu'ti
Keywords: diabetes mellitus;, acute complication;, diabetic ketoasidosis;

Abstract

Diabetic ketoacidosis (DKA) is one of the acute complications of hyperglycemic crises from diabetes mellitus (DM). DKA cases have seen an increase in hospitalization and mortality rates over past years. Studies of DKA in Indonesian are still limited and usually found in certain hospitals with relatively high mortality findings. This study aims to describe the characteristics of DKA patients at Regional Hospital Abdul Wahab Sjahranie Samarinda 2017 – 2020 period. This study used a descriptive observational design and identification patient medical records. Variables studied including age, gender, type of DM, history of infection, severity of DKA, and mortality. Sample in this study amounted to 59 patients and were taken using the total sample method. This studies found two thirds of the patients were in the adult age group (>18 – 60 years old) (67,8%), were female (66,7%), and had DM type 2 (67,8%). Almost all patients (93,2%) had a history of infection that precipitated DKA. A total of 9 (15,2%) and  46 (78%) patients had moderate and severe DKA. Amount 23 of 59 (39%) patients died during admissions. Most of DKA patients are adult age group, female, had DM type 2, and experience severe DKA. The rate of infection history and mortality of DKA patients in this study were relatively high compared to other studies.

References

Almalki, M. H. et al. (2016) ‘Clinical and biochemical characteristics of diabetes ketoacidosis in a tertiary hospital in Riyadh’, Clinical Medicine Insights: Endocrinology and Diabetes, 9, pp. 7–11. doi: 10.4137/CMED.S39639.

Alotaibi, A. et al. (2020) ‘Diabetic Ketoacidosis Treatment Outcome and Associated Factors Among Adult Patients Admitted to the Emergency Department and Medical Wards at King Abdulaziz Medical City, Riyadh, Saudi Arabia’, Cureus, 12(8), pp. 1–15. doi: 10.7759/cureus.10067.

Arora, S. et al. (2011) ‘Diagnostic accuracy of point-of-care testing for diabetic ketoacidosis at emergency-department triage: β-hydroxybutyrate versus the urine dipstick’, Diabetes Care, 34(4), pp. 852–854. doi: 10.2337/dc10-1844.

Balitbang Kemenkes RI. (2019) ‘Laporan Nasional Riset Kesehatan Dasar 2018’. Jakarta: Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan.

Barski, L. et al. (2013) ‘Comparison of diabetic ketoacidosis in patients with type-1 and type-2 diabetes mellitus’, American Journal of the Medical Sciences, 345(4), pp. 326–330. doi: 10.1097/MAJ.0b013e31827424ab.

Benoit, S. R. et al. (2018) ‘Trends in Diabetic Ketoacidosis Hospitalizations and In-Hospital Mortality — United States, 2000–2014’, MMWR. Morbidity and Mortality Weekly Report, 67(12), pp. 362–365. doi: 10.15585/mmwr.mm6712a3.

Dewata, D. G. U. B., Novida, H. and Aryati, A. (2020) ‘Profile of Diabetic Ketoacidosis Patients At Regional Public Hospital Dr. Soetomo in 2017’, Jurnal Berkala Epidemiologi, 8(3), p. 301. doi: 10.20473/jbe.v8i32020.301-309.

European Association of Urology. (2018) ‘Guidelines on Urological Infections’, European Association of Urology. Available at: http://www.uroweb.org/gls/pdf/15_Urological_Infections.pdf.

George, J. T., Mishra, A. K. and Iyadurai, R. (2018) ‘Correlation between the outcomes and severity of diabetic ketoacidosis: A retrospective pilot study’, Journal of Family Medicine and Primary Care, 6(2), pp. 169–170. doi: 10.4103/jfmpc.jfmpc.

Gibb, F. W. et al. (2016) ‘Risk of death following admission to a UK hospital with diabetic ketoacidosis’, Diabetologia, 59(10), pp. 2082–2087. doi: 10.1007/s00125-016-4034-0.

Hamed, Z. S. et al. (2017) ‘Epidemiology of infection as a precipitating factor for diabetic ketoacidosis at Tanta University Hospital’, Tanta Medical Journal, 45(2), p. 68. doi: 10.4103/tmj.tmj_10_17.

Hua-Fen, C. et al. (2009) ‘Short-Term Case Fatality Rate and Associated Factors among Inpatients with Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State : A Hospital-Based Analysis over a 15-Year Period’, Internal Medicine, 49(5), pp. 729–737. doi: 10.2169/internalmedicine.49.2965.

International Diabetes Federation. (2019) ‘IDF Diabetes Atlas (9th ed.)’. International Diabetes Federation.

Kitabchi, A. E. et al. (2009) ‘Hyperglycemic crises in adult patients with diabetes’, Diabetes Care, 32(7), pp. 1335–1343. doi: 10.2337/dc09-9032.

Kuru, B. et al. (2014) ‘Comparing finger-stick β-hydroxybutyrate with dipstick urine tests in the detection of ketone bodies’, Turkiye Acil Tip Dergisi, 14(2), pp. 47–52. doi: 10.5505/1304.7361.2014.14880.

Lee, P. G. and Halter, J. B. (2017) ‘The pathophysiology of hyperglycemia in older adults: Clinical considerations’, Diabetes Care, 40(4), pp. 444–452. doi: 10.2337/dc16-1732.

Lee, H. J. et al. (2017) ‘Factors associated with the presence and severity of diabetic ketoacidosis at diagnosis of type 1 diabetes in Korean children and adolescents’, Journal of Korean Medical Science, 32(2), pp. 303–309. doi: 10.3346/jkms.2017.32.2.303.

Nyenwe, E. A. and Kitabchi, A. E. (2016) ‘The evolution of diabetic ketoacidosis: An update of its etiology, pathogenesis and management’, Metabolism: Clinical and Experimental, 65(4), pp. 507–521. doi: 10.1016/j.metabol.2015.12.007.

Pulungan, A. B., Annisa, D. and Imada, S. (2019) ‘Diabetes Melitus Tipe-1 pada Anak: Situasi di Indonesia dan Tata Laksana’, Sari Pediatri, 20(6), p. 392. doi: 10.14238/sp20.6.2019.392-400.

Puttanna, A. and Padinjakara, R. N. K. (2014) ‘Diabetic ketoacidosis in type 2 diabetes mellitus’, Practical Diabetes, 31(4), pp. 155–158. doi: 10.1002/pdi.1852.

Radhi, H. T. et al. (2020) ‘Characteristics of Diabetic Ketoacidosis in Adult Patients in Bahrain’, Clnical Investigation, 10(1), pp. 18–27. doi: 10.1111/j.1532-5415.1993.tb06193.x.

Ramphul, K. and Joynauth, J. (2020) ‘An Update on the Incidence and Burden of Diabetic Ketoacidosis in the U.S.’, Diabetes Care, 43(December), p. dc201258. doi: 10.2337/dc20-1258.

Sato, Y. et al. (2021) ‘Factors affecting in-hospital mortality of diabetic ketoacidosis patients: A retrospective cohort study’, Diabetes Research and Clinical Practice, 171, p. 108588. doi: 10.1016/j.diabres.2020.108588.

Schwarzfuchs, D. et al. (2020) ‘Clinical and Epidemiological Characteristics of Diabetic Ketoacidosis in Older Adults’, Journal of the American Geriatrics Society, 68(6), pp. 1256–1261. doi: 10.1111/jgs.16376.

Seth, P., Kaur, H. and Kaur, M. (2015) ‘Clinical profile of diabetic ketoacidosis: A prospective study in a tertiary care hospital’, Journal of Clinical and Diagnostic Research, 9(6), pp. OC01–OC04. doi: 10.7860/JCDR/2015/8586.5995.

Shahid, W. et al. (2020) ‘Diabetic Ketoacidosis: Clinical Characteristics and Precipitating Factors’, Cureus, 12(10), pp. 2018–2021. doi: 10.7759/cureus.10792.

Sonwani, S., Arya, A. and Saxena, R. S. (2018) ‘A Prospective Study of Risk Factors, Clinical Profile and Outcome in Patients of Diabetic Ketoacidosis (DKA) in Type II Diabetes Patients’, International Journal of Contemporary Medical Research [IJCMR], 5(4), pp. 21–24. doi: 10.21276/ijcmr.2018.5.4.15.

Suwarto, S. et al. (2014) ‘Predictors of five days mortality in diabetic ketoacidosis patients: a prospective cohort study’, Acta medica Indonesiana, 46(1), pp. 18–23.

Thewjitcharoen, Y. et al. (2019) ‘Clinical characteristics and outcomes of care in adult patients with diabetic ketoacidosis: A retrospective study from a tertiary diabetes center in Thailand’, Journal of Clinical and Translational Endocrinology, 16(March), p. 100188. doi: 10.1016/j.jcte.2019.100188.

Usman, A. et al. (2015) ‘Profiles of diabetic ketoacidosis in multiethnic diabetic population of Malaysia’, Tropical Journal of Pharmaceutical Research, 14(1), pp. 179–185. doi: 10.4314/tjpr.v14i1.25.

Wibawa, A. S. et al. (2020) ‘Risk Factor Related to Mortality of Diabetic Ketoacidosis Patients in Dr. Soetomo General Hospital Surabaya’, JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 11(1), p. 36. doi: 10.20473/juxta.v11i12020.36-40.

World Health Organization. (‎2016)‎ ‘Global report on diabetes’. World Health Organization. https://apps.who.int/iris/handle/10665/204871

Published
2021-10-05
Section
Articles
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