SYSTEMATIC REVIEW TENTANG DISTRIBUSI M. TUBERCULOSIS GENOTIP BEIJING PADA PASIEN TUBERCULOSIS PARU
Keywords:
COVID-19;, East Kalimantan;, Gender;, Age;
Abstract
Nama: Yedial Dwi Putra Simangunsong
Program Studi : Kedokteran
Judul : Systematic review tentang Distribusi Mycobacterium tuberculosis Genotip Beijing Pada Pasien Tuberculosis Paru
Tuberkulosis atau TB adalah suatu penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Tuberkulosis masih merupakan masalah kesehatan masyarakat yang menjadi tantangan global. TB sendiri memiliki banyak genotip secara genetic yang penting antara lain Haarlem, W/Beijing, Latino-American dan Mediterranean (LAM), Central Asian (CAS) dan East-African-Indian (EAI). Diantara genotip-genotip diatas, Beijing merupakan genotip yang bertanggung jawab atas terjadinya epidemic TB. Mycobacterium tuberculosis genotip Beijing ini pertama kali ditemukan di China dan merupakan negara dengan salah satu persebaran genotip Beijing terbesar yang ada di dunia. Systematic review ini bertujuan untuk mengetahui distribusi dari Mycobacterium tuberculosis genotip Beijing dan mencari hubungan dengan usia dan resisten obat. Systematic review ini dilakukan dengan pencarian studi pada database atau search engine yang dapat dicari di Google Scholar, Pubmed, atau Reseacrh Gate, dalam Bahasa Indonesia dan Bahasa Inggris. Hasil pencarian telah diperoleh sebanyak 75 studi dan tersisa 30 studi yang memenuhi kriteria inklusi. Hasil dari pencarian menunjukkan bahwa distribusi Mycobacterium tuberculosis genotip Beijing tertinggi berada di Asia dengan negara China sebagai negara dengan penderita terbanyak diikuti oleh negara Asia tenggara seperti Vietnam. Hasil penelitian studi yang membahas tentang hubungan dengan usia 50% menunjukkan adanya signifikansi, hubungan dengan resistensi obat menunjukkan tidak ada nya signifikasi dari studi yang membahas tentang resistensi obat. Disimpulkan bahwa distribusi Mycobacterium tuberculosis genotip Beijing memiliki 23,7% pasien dengan persebaran tertinggi berada di benua Asia, banyak didapatkan pada pasien dengan usia yang produktif dan lebih beresiko untuk mengalami resistensi obat karena adanya mutasi.
Kata Kunci : Mycobacterium tuberculosis genotip Beijing, usia, resisten obat
References
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24. Parwati, I., Alisjahbana, B., Apriani, L., Soetikno, R. D., Ottenhoff, T. H., Van Der Zanden, A. G. M., Van Meer, J. Der, Van Soolingen, D., & VanCrevel, R. (2010). Mycobacterium tuberculosis Beijing genotype is an independent risk factor for tuberculosis treatment failure in Indonesia. Journal of Infectious Diseases, 201(4), 553–557. https://doi.org/10.1086/650311
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29. Sinha, P., Gupta, A., Prakash, P., Anupurba, S., Tripathi, R., & Srivastava, G. N. (2016). Differentiation of Mycobacterium tuberculosis complex from non-tubercular mycobacteria by nested multiplex PCR targeting IS6110, MTP40, and 32kD alpha antigen encoding gene fragments. BMC Infectious Diseases, 16(1). https://doi.org/10.1186/s12879-016-1450-1
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33. Toungoussova, O. S., Bjune, G., & Caugant, D. A. (2006). Epidemic of tuberculosis in the former Soviet Union : Social and biological reasons. https://doi.org/10.1016/j.tube.2005.04.001
34. Van Crevel, R., Nelwan, R. H. H., De Lenne, W., Veeraragu, Y., Van Der Zanden, A. G., Amin, Z., Van Der Meer, J. W. M., & Van Soolingen, D. (2001). Mycobacterium tuberculosis Beijing genotype strains associated with febrile response to treatment. Emerging Infectious Diseases, 7(5), 880–883. https://doi.org/10.3201/eid0705.017518
35. Van Soolingen, D., Qian, L., De Haas, P. E. W., Douglas, J. T., Traore, H., Portaels, F., Huang Zi Qing, Enkhsaikan, D., Nymadawa, P., & Van Embden, J. D. A. (1995). Predominance of a single genotype of Mycobacterium tuberculosis in countries of East Asia. Journal of Clinical Microbiology, 33(12), 3234–3238. https://doi.org/10.1128/jcm.33.12.3234-3238.1995
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2. Bifani, P. J., Mathema, B., Liu, Z., Moghazeh, S. L., Shopsin, B., Tempalski, B., Driscoll, J., Frothingham, R., Musser, J. M., Alcabes, P., & Kreiswirth, B. N. (1999). Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology. Journal of the American Medical Association, 282(24), 2321–2327. https://doi.org/10.1001/jama.282.24.2321
3. C, S., A, D., L, H., J, M., I, F., & E, L. (1999). Tuberculosis in the Caribbean: using spacer oligonucleotide typing to understand strain origin and transmission.
4. CDC. (2006). Emerging Infectious Diseases. Tuberculosis. www.cdc.gov/eid
5. Center for Disesase Control and Preventation. (2018). TUBERCULOSIS. Center for Disease Control and Prevention. https://www.cdc.gov/tb/
6. Drobniewski, F., Ruddy, M., Melentyev, A., & Fedorin, I. (2005). Clinical Virulence, and the Dominance of the Beijing Strain Family in Russia. Erasmus, 293(22), 2726–2731.
7. Duong, D. A., Duyen, N. T. H., Lan, N. T. N., Dai, V. H., Ha, D. T. M., Vo, S. K., Thu, D. D. A., Chau, N. V. V., Nguyen, H. D., Dinh, N. S., Farrar, J., & Caws, M. (2009). Beijing genotype of Mycobacterium tuberculosis is significantly associated with high-level fluoroquinolone resistance in Vietnam. Antimicrobial Agents and Chemotherapy, 53(11), 4835–4839. https://doi.org/10.1128/AAC.00541-09
8. Glynn, J. R., Whiteley, J., Bifani, P. J., Kremer, K., & Soolingen, D. Van. (2002). Worldwide Occurrence of Beijing / W Strains of Mycobacterium tuberculosis : A Systematic Review. 8(8).
9. H, S., X, P., A, A., EA, G., A, S., & JM, M. (2000). Characterization of Mycobacterium tuberculosis isolates from patients in Houston, Texas, by spoligotyping.
10. Hanekom, M., Van Der Spuy, G. D., Streicher, E., Ndabambi, S. L., McEvoy, C. R. E., Kidd, M., Beyers, N., Victor, T. C., Van Helden, P. D., & Warren, R. M. (2007). A recently evolved sublineage of the Mycobacterium tuberculosis Beijing strain family is associated with an increased ability to spread and cause disease. Journal of Clinical Microbiology, 45(5), 1483–1490. https://doi.org/10.1128/JCM.02191-06
11. JA, C., MJ, P., MI, C.-H., JC, R., I, G., & P, C. (2001). Epidemiological evidence of the spread of a Mycobacterium tuberculosis strain of the Beijing genotype on Gran Canaria Island.
12. Jasaputra, D. K., Widjaja, J. T., Wargasetia, T. L., & Makangiras, I. (2007). Deteksi Mycobacterium tuberculosis dengan Teknik PCR pada Cairan Efusi Pleura Penderita Tuberkulosis Paru. Jkm.
13. Jou, R., Chiang, C. Y., & Huang, W. L. (2005). Distribution of the Beijing family genotypes of Mycobacterium tuberculosis in Taiwan. Journal of Clinical Microbiology, 43(1), 95–100. https://doi.org/10.1128/JCM.43.1.95-100.2005
14. Peraturan Kesehatan Republik Indonesia No.67Tahun 2016 Tentang Penanggulangan Tuberkulosis, Pub. L. No. 67 (2016).
15. Kementerian Kesehatan Republik Indonesia. (2018). Data dan Informasi Profil Kesehatan Indonesia 2017. https://doi.org/10.1002/qj
16. Kementerian Kesehatan Republik Indonesia. (2019). Data dan Informasi Profil Kesehatan Indonesia 2018. Data Dan Informasi Profil Kesehatan Indonesia.
17. Kitchenham. (2004). Procedures for Performing Systematic Reviews. https://doi.org/10.1145/3328905.3332505
18. Kumar, V., Abbas, A. K., & Aster, J. C. (2013). Robbins BASIC PATHOLOGY. In Journal of Chemical Information and Modeling (Vol. 53, Issue 9). https://doi.org/10.1017/CBO9781107415324.004
19. Lisdawati, V., Puspandari, N., & Parwati, I. (2010). Studi Pemetaan Awal DNA Mycobacterium tuberculosis complex secara Spoligotyping pada Hasil Isolasi Dahak Pasien Tuberculosis Paru dari 10 Ibu Kota Provinsi.
20. M, D., K, K., EA, B., MR, K., D, V. S., & Ghaderi, A. (2000). IS6110-RFLP and spoligotyping of Mycobacterium tuberculosis isolated in Iran.
21. Marais, B. J., Victor, T. C., Hesseling, A. C., Barnard, M., Jordaan, A., Brittle, W., Reuter, H., Beyers, N., Van Helden, P. D., Warren, R. M., & Schaaf, H. S. (2006). Beijing and Haarlem genotypes are overrepresented among children with drug-resistant tuberculosis in the Western Cape province of South Africa. Journal of Clinical Microbiology, 44(10), 3539–3543. https://doi.org/10.1128/JCM.01291-06
22. MN, N., YG, de la S., A, S., AA, H., MF, C., & B, G. (1999). Characterization of M. tuberculosis strains from west African patients by spoligotyping.
23. MY, C., M, B., CW, Y., PE, de H., WS, W., & KM, K. (2001). Seventy percent of the Mycobacterium tuberculosis isolates in Hong Kong represent the Beijing genotype.
24. Parwati, I., Alisjahbana, B., Apriani, L., Soetikno, R. D., Ottenhoff, T. H., Van Der Zanden, A. G. M., Van Meer, J. Der, Van Soolingen, D., & VanCrevel, R. (2010). Mycobacterium tuberculosis Beijing genotype is an independent risk factor for tuberculosis treatment failure in Indonesia. Journal of Infectious Diseases, 201(4), 553–557. https://doi.org/10.1086/650311
25. Parwati, I., Alisjahbana, B., Teirlinck, A. C., Ridhayanti, P. T., van der Ven, A. J., Netea, M. G., de Lange, W., Soeroto, A. Y., Sampoerno, H., van der Werf, M., & van Crevel, R. (2017). Death, Recurrent Tuberculosis and Lung Function Impairment After Tuberculosis Treatment in Indonesia. In I. Parwati (Ed.), Factors Underlying the Success of the Mycobacterium tuberculosis Beijing Genotype in Indonesia. Pustaka Billah.
26. Parwati, I., van Crevel, R., Sudiro, T. M., Alisjahbana, B., Pakasi, T., Kremer, K., van der Zanden, A. G. ., & Soolingen, D. Van. (2017). The Population Structure of Mycobacterium tuberculosis Differs Significantly on Two Indonesian Islands. In I. Parwati (Ed.), Factors Underlying the Success of the Mycobacterium tuberculosis Beijing Genotype in Indonesia. Pustaka Billah.
27. Phyu, S., Stavrum, R., Lwin, T., Svendsen, Ø. S., Ti, T., & Grewal, H. M. S. (2009). Predominance of Mycobacterium tuberculosis EAI and Beijing lineages in Yangon, Myanmar. Journal of Clinical Microbiology, 47(2), 335–344. https://doi.org/10.1128/JCM.01812-08
28. Qian, L., Van Embden, J. D. A., Van Der Zanden, A. G. M., Weltevreden, E. F., Duanmu, H., & Douglas, J. T. (1999). Retrospective analysis of the Beijing family of Mycobacterium tuberculosis in preserved lung tissues. Journal of Clinical Microbiology, 37(2), 471–474. https://doi.org/10.1128/jcm.37.2.471-474.1999
29. Sinha, P., Gupta, A., Prakash, P., Anupurba, S., Tripathi, R., & Srivastava, G. N. (2016). Differentiation of Mycobacterium tuberculosis complex from non-tubercular mycobacteria by nested multiplex PCR targeting IS6110, MTP40, and 32kD alpha antigen encoding gene fragments. BMC Infectious Diseases, 16(1). https://doi.org/10.1186/s12879-016-1450-1
30. Soolingen, Dick Van. (2001). Molecular Epidemiology of Tuberculosis and Other Other Mycobacterial Infections : Main Methodologies and Achievement.
31. Sundari, R., Parwati, I., Mose, J. C., & Setiabudiawan, B. (2017). Perbedaan Parameter Hematologi pada Penderita Tuberkulosis Paru Terinfeksi Mycobacterium Tuberculosis Galur Beijing dengan Galur Non- Beijing. 49(1).
32. Syahridha, Mertaniasih, N. M., Florentina, S., & Soedarsono. (2019). ACID-FAST BACILLI CONVERSION OF BEIJING AND NON- BEIJING STRAIN OF PULMONARY TUBERCULOSIS IN SOUTH SULAWESI. 7(5).
33. Toungoussova, O. S., Bjune, G., & Caugant, D. A. (2006). Epidemic of tuberculosis in the former Soviet Union : Social and biological reasons. https://doi.org/10.1016/j.tube.2005.04.001
34. Van Crevel, R., Nelwan, R. H. H., De Lenne, W., Veeraragu, Y., Van Der Zanden, A. G., Amin, Z., Van Der Meer, J. W. M., & Van Soolingen, D. (2001). Mycobacterium tuberculosis Beijing genotype strains associated with febrile response to treatment. Emerging Infectious Diseases, 7(5), 880–883. https://doi.org/10.3201/eid0705.017518
35. Van Soolingen, D., Qian, L., De Haas, P. E. W., Douglas, J. T., Traore, H., Portaels, F., Huang Zi Qing, Enkhsaikan, D., Nymadawa, P., & Van Embden, J. D. A. (1995). Predominance of a single genotype of Mycobacterium tuberculosis in countries of East Asia. Journal of Clinical Microbiology, 33(12), 3234–3238. https://doi.org/10.1128/jcm.33.12.3234-3238.1995
36. Wirth, T., Hildebrand, F., Allix-Béguec, C., Wölbeling, F., Kubica, T., Kremer, K., Van Soolingen, D., Rüsch-Gerdes, S., Locht, C., Brisse, S., Meyer, A., Supply, P., & Niemann, S. (2008). Origin, spread and demography of the Mycobacterium tuberculosis complex. PLoS Pathogens, 4(9). https://doi.org/10.1371/journal.ppat.1000160
37. World Health Organization. (2019). Global Tuberculosis Report 2019.
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