DERAJAT HISTOPATOLOGI BERHUBUNGAN DENGAN EKSPRESI Ki-67 PADA KANKER PAYUDARA INVASIF NO SPECIAL TYPE DI RSUD ABDUL WAHAB SJAHRANIE SAMARINDA

  • Annisa Program Studi Kedokteran, Fakultas Kedokteran, Universitas Mulawarman
  • Hadi Laboratorium Patologi Anatomi, Fakultas Kedokteran, Universitas Mulawarman
  • Nurul Laboratorium Histologi, Fakultas Kedokteran, Universitas Mulawarman
Keywords: Breast cancer, Histologic grade, Ki-67

Abstract

The incidence and mortality of breast cancer ranks second and fifth in the world. No Special Type (NST) invasive breast cancers is found in about 70-80% of all invasive breast cancers and has worse prognosis than other types. Currently, prognostic factors have been developed, one of them is Ki-67. Ki-67 is a protein-nucleus known as the marker of cell proliferation rate. This study aims to determine the correlation between histologic grade towards the expression of Ki-67 in NST invasive breast cancer patients. An analytical cross-sectional study was conducted in RSUD Abdul Wahab Sjahranie Samarinda by using 61 subjects. The histologic grade and Ki-67 expression were recorded from medical records. The results showed a correlation between histologic grade with Ki-67 (p=0.029). Histologic grade is significantly correlated with Ki-67 expression. It can be concluded that the worse the histologic grade of the breast cancer is, the higher the expression of Ki-67 will be.

References

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492

Chen, H. L., Ding, A., & Wang, F. W. (2015). Prognostic effect analysis of molecular subtype on young breast cancer patients. Chinese Journal of Cancer Research, 27(4), 428.

Ermiah, E., Buhmeida, A., Abdalla, F., Khaled, B. R., Salem, N., Pyrhönen, S., & Collan, Y. (2012). Prognostic value of proliferation markers: immunohistochemical ki-67 expression and cytometric s-phase fraction of women with breast cancer in Libya. Journal of Cancer, 3, 421.

Globocan. (2020). Indonesia. Search: Globocan 2020. Diakses November 2020 dari https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf
Gulzar, R., Shahid, R., & Saleem, O. (2018). Molecular subtypes of breast cancer by immunohistochemical profiling. Int. j. pathol, 16(2), 129-134.

Hutagalung, S., Mulyadi, I., & Artha, I. (2014). Ekspresi Ki-67 dan HER-2/neu Berhubungan dengan Derajat Histopatologik Karsinoma Payudara Invasif No Special Type (NST). Majalah Patologi, 23(2).

Joensuu, K., Leidenius, M., Kero, M., Andersson, L. C., Horwitz, K. B., & Heikkilä, P. (2013). ER, PR, HER2, Ki-67 and CK5 in early and late relapsing breast cancer—Reduced CK5 expression in metastases. Breast cancer: basic and clinical research, 7, BCBCR-S10701.

Makki, J. (2015). Diversity of breast carcinoma: histological subtypes and clinical relevance. Clinical Medicine Insights: Pathology, 8, CPath-S31563.

Ragab, H. M., Samy, N., Afify, M., Abd El Maksoud, N., & Shaaban, H. M. (2018). Assessment of Ki-67 as a potential biomarker in patients with breast cancer. Journal of Genetic Engineering and Biotechnology, 16(2), 479-484.

Rakha E.A., Reis-Filho J.S., Baehner F., Dabbs D.J., Decker T., Eusebi V., Fox S.B., Ichihara S., Jacquemier J., Lakhani S.R., Palacios J., Richardson A.L., Schnitt S.J., Schmitt F.C., Tan P., Tse G.M., Badve S., and Ellis I.O. (2010). Breast cancer prognostic classification in the molecular era: the role of histopatological grade. Breast Cancer Research, 12, 207.

Togatorop, M. P. (2014). Hubungan Antara Grading Histopatologi dengan Ekspresi Ki-67 Penderita Kanker Payudara di Rumah Sakit Haji Adam Malik Medan. Disertasi. Program Pendidikan Dokter Spesialis Universitas Sumatera Utara. Medan. Diakses Mei 2021 dari http://repositori.usu.ac.id/handle/123456789/35492

Windarti, I. (2014). Characteristic Of Breast Cancer In Young Women In H. Abdul Moeloek Hospital Bandar Lampung. Juke Unila, 4(07).
Published
2022-03-31
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Articles
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