• Theresia Yulia Manibuy Program Studi Kedokteran
  • Nataniel 1. Program Studi Kedokteran, Fakultas Kedokteran Universitas Mulawarman 2. Laboratorium Ilmu Mikrobiologi, Fakultas Kedokteran Universitas Mulawarman
  • Khemasili 3. Laboratorium Ilmu Farmakologi, Fakultas Kedokteran Universitas Mulawarman
  • Mona 4. Laboratorium Ilmu Parasitologi, Fakultas Kedokteran Universitas Mulawarman
Keywords: Cholelithiasis, Prophylactic Antibiotics, Laparoscopic Cholecystectomy, Surgical Site Infection, Meta-Analysis


Cholelithiasis is a gastrointestinal disease commonly found in doctors’ daily medical practice. It has occurred in 20 to 25 million people, representing 10-15% of adults in United States of America. The treatment of cholelithiasis consists of two methods, i.e., surgical method and non-surgical method. Laparoscopic cholecystectomy is a surgical method and the standard treatment in symptomatic cholelithiasis. Surgical site infection is an infection that may occur in patients undergoing surgery. One way to prevent surgical site infection after laparoscopic cholecystectomy is using antibiotics as prophylaxis. This meta-analysis aims to depict the statistical data on the influence of prophylactic antibiotics towards the occurrence of surgical site infection in patients with cholelithiasis after laparoscopic cholecystectomy. Journals that were analyzed were journals in English obtained through online database, e.g., Google Scholar, PubMed, and Springer within 2001- 2021 publication period. From the search result, 7,215 journals have been found that after getting critical review, 7 of them were selected. The method of analysis employed in this research was fixed effects model, and the data were analyzed using comprehensive meta-analysis software v3 trial. The result showed that the score of summary effect RR = 1.082 with significance test of p-value of 0.786 (p > 0.05 with 95% confidence interval). Thus, this research concludes that prophylactic antibiotics treatment has no significant influence towards the occurrence of surgical site infection in patients with cholelithiasis after laparoscopic cholecystectomy.


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